New CNS depressant cardenolide glycoside from the roots of Nerium oleander

Case of Poisoning from the Oleander Root (Nerium Odorum)

Absorption of Formaldehyde by Oleander (Nerium indicum).

Azeroside C: a new phloroacetophenone glycoside from the roots of Dorema glabrum Fisch. & C.A. Mey

Background and objectives: Dorema glabrum Fisch. & C.A. Meyfrom Umbelliferae family is a monocarpic species distributed in north-west of Iran, Azerbaijan republic and Armenia. The gum-resin of this species is traditionally used for the treatment of bronchitis, catarrh and diarrhea, as well as for its diuretic properties. Recently, we have reported the isolation of five...

Experimental oleander (Nerium oleander) intoxication in broiler chickens (Gallus gallus).

Dried leaves of oleander were orally given at a single dose of 500 mg/kg body weight to 20 clinically healthy male chickens. Clinical signs of toxicosis began to appear about 1 h after receiving the oleander and included hypersalivation, vomiting, diarrhea, deep depression, and sudden death. Also, hyperemia in the combs and wattles was obviously seen. Electrocardiograms (ECG) were repeatedly re...

CNS depressant activities of roots of Coccos nucifera in mice.

The ethanol extract of Coccos nucifera (EECN) was tested for possible pharmacological effects on experimental animals. EECN significantly potentiated the sleeping time of mice induced by standard hypnotics viz. pentobarbital sodium, diazepam, and meprobamate in a dose dependent manner. EECN showed significant analgesic properties as evidenced by the significant reduction in the number of writhe...